NFL Week 6 picks, predictions: Will 49ers, Bucs, Eagles, Bengals, Bills win crucial games? (2024)

Jeremy CluffArizona Republic

NFL Week 6 picks, predictions: Will 49ers, Bucs, Eagles, Bengals, Bills win crucial games? (1)

NFL Week 6 picks, predictions: Will 49ers, Bucs, Eagles, Bengals, Bills win crucial games? (2)

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The 2024 NFL season continues with an NFL Week 6 schedule filled with crucial games, with some teams really needing a victory.

The San Francisco 49ers and Seattle Seahawks play on Thursday Night Football. The Jacksonville Jaguars face the Chicago Bears in London on Sunday morning.

The Washington Commanders take on the Baltimore Ravens on Sunday, while the Detroit Lions are at the Dallas Cowboys.

The Cincinnati Bengals and New York Giants play on Sunday Night Football, with the week ending with the Buffalo Bills at the New York Jets on Monday Night Football.

Which teams will get wins in their crucial NFL Week 6 games?

Check out our NFL Week 6 picks and NFL Week 6 predictions for the 14 NFL games this week.

All times MST.

NFL Week 6 picks: 49ers vs Seahawks | Jaguars vs Bears | Commanders vs Ravens | Cardinals vs Packers | Texans vs Patriots | Buccaneers vs Saints | Browns vs Eagles | Colts vs Titans | Chargers vs Broncos | Steelers vs Raiders | Falcons vs Panthers | Lions vs Cowboys | Bengals vs Giants | Bills vs Jets | The Arizona Republic's predictions

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Thursday Night Football prediction, Oct. 10

San Francisco 49ers vs Seattle Seahawks, 5:15 p.m., Prime Video (stream on Amazon)

What's going on with the 49ers? Their problems seem to extend far beyond just being without Christian McCaffrey. Still, San Francisco would tie for the NFC West division lead with a win in this game.

Prediction: 49ers 24, Seahawks 21

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Sunday morning London game prediction, Oct. 13

Jacksonville Jaguars vs Chicago Bears, 6:30 a.m., NFL Network (stream with free trial from FUBO)

How good is the NFC North? The Bears are 3-2 and tied for last in the division. Caleb Williams and Chicago will be too much for the Jaguars at home.

Prediction: Bears 27, Jaguars 17

NFL Week 6 schedule: Television channels, how to watch, stream games this week

Sunday early NFL football game predictions, Oct. 13

Washington Commanders vs Baltimore Ravens, 10 a.m., CBS (stream with free trial from FUBO)

The Washington Commanders are one of the surprises of the NFL season, but it would surprise us if they beat the Ravens in Baltimore. Lamar Jackson could go off in this game.

Prediction: Ravens 30, Commanders 23

Arizona Cardinals vs Green Bay Packers, 10 a.m., FOX (stream with free trial from FUBO)

Kyler Murray and the Arizona Cardinals impressed in their Week 5 win over the 49ers but winning at Lambeau on the road early in the morning will be too difficult a task.

Prediction: Packers 27, Cardinals 23

Houston Texans vs New England Patriots, 10 a.m., CBS (stream with free trial from FUBO)

The Patriots have lost four straight games since opening the season with a victory. C.J. Stroud and the Texans will make it five straight losses here.

Prediction: Texans 24, Patriots 13

Tampa Bay Buccaneers vs New Orleans Saints, 10 a.m., FOX (stream with free trial from FUBO)

Baker Mayfield and Tampa Bay have been off since Thursday Night Football in NFL Week 5. That rest advantage will work wonders late against the Saints.

Prediction: Buccaneers 28, Saints 24

Cleveland Browns vs Philadelphia Eagles, 10 a.m., FOX (stream with free trial from FUBO)

It's going to be a long season in Cleveland, and this game could be a very long game for Deshaun Watson and the Browns. Jalen Hurts and the Eagles will roll.

Prediction: Eagles 31, Browns 14

Indianapolis Colts vs Tennessee Titans, 10 a.m., CBS (stream with free trial from FUBO)

Sometimes a game simply comes down to quarterbacks and we feel better about the Colts' QBs.

Prediction: Colts 23, Titans 20

Sunday late NFL football game predictions, Oct. 13

Los Angeles Chargers vs Denver Broncos, 1:05 p.m., CBS (stream with free trial from FUBO)

The Broncos have won three straight games and the Chargers have lost two in a row. Denver's defense will be the difference in this AFC West game.

Prediction: Broncos 21, Chargers 17

Pittsburgh Steelers vs Las Vegas Raiders, 1:05 p.m., CBS (stream with free trial from FUBO)

The Steelers' defense should feast on the Raiders, no matter who plays QB for Las Vegas.

Prediction: Steelers 20, Raiders 10

Atlanta Falcons vs Carolina Panthers, 1:25 p.m., FOX (stream with free trial from FUBO)

Kirk Cousins and the Falcons play on the road for just the second time this season. They'll get a test from the Panthers, but pull away late.

Prediction: Falcons 27, Panthers 16

Detroit Lions vs Dallas Cowboys, 1:25 p.m., FOX (stream with free trial from FUBO)

The Lions were off in Week 5, giving them an extra week to prepare for Dak Prescott and the Cowboys. Bad news for Dallas.

Prediction: Lions 31, Cowboys 20

NFL Week 6 odds: Point spreads, moneylines, over/unders for betting on games this week

Sunday Night Football prediction, Oct. 13

Cincinnati Bengals vs New York Giants, 5:20 p.m., NBC (stream with Peacock)

The Bengals really can't fall to 1-5, can they? Cincinnati has had some tough losses. It will have a big win against the Giants in Week 6.

Prediction: Bengals 34, Giants 20

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Monday Night Football prediction, Oct. 14

Buffalo Bills vs New York Jets, 5:15 p.m., ESPN, ESPN2 (stream with free trial from FUBO)

Both teams have lost two in a row and can't afford a third straight defeat. We expect a shootout on Monday night, with Josh Allen making a key play late to secure the win for Buffalo.

Prediction: Bills 30, Jets 27

The Kansas City Chiefs, Los Angeles Rams, Miami Dolphins and Minnesota Vikings are off this week.

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Reach Jeremy Cluffatjeremy.cluff@arizonarepublic.com.Follow him on X, formerly Twitter@Jeremy_Cluff.

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NFL Week 6 picks, predictions: Will 49ers, Bucs, Eagles, Bengals, Bills win crucial games? (2024)

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